TMan has used some of his materials in non-equilibrium state for a long time. Glasses are typical example of substances in frozen-in disordered state which was realized by non-equilibrium processing. Thermodynamic characterization of molecular glasses was described briefly. Formation of non-crystalline solids by various kinds of non-equilibrium processing other than the traditional liquid cooling was discussed. Solid-state vitrification by mechanical milling and formation of molecular alloys for some binary systems were described with potential application to pharmaceuticals.