In order to help struggling students master the subjects of physical chemistry in the Chemistry department, a blended learning approach is adopted to include the following: (1) delivery of a recorded lecture by video-on-demand, (2) support from student assistants both in class and online, (3) group study and team-based learning in the classroom, (4) lectures designed to help students master the content, and (5) participative learning encouraged by the use of a clicker in class. The video-on-demand system is effective for real-time reservation of study at home. Significant positive correlations are confirmed between the degree of achievement and browse times of live video of lectures, group study, team-based learning, satisfaction with the lectures, and efficient utilization of clickers in class.